How PEGylation influences protein conformational stability
نویسندگان
چکیده
منابع مشابه
Protein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کاملprotein stability, folding, disaggregation and etiology of conformational malfunctions
estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. a...
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Protein search and association to specific sequences on DNA is a starting point for all fundamental biological processes. It has been intensively studied in recent years by a variety of experimental and theoretical methods. However, many features of these complex biological phenomena are still not resolved at the molecular level. Experiments indicate that proteins can be bound nonspecifically t...
متن کاملHow the generalized anomeric effect influences the conformational preference.
The generalized anomeric effect refers to the conformational preference of a gauche structure over an anti structure for molecules with a R-X-C-Y moiety. Whereas there are conflicting reports regarding the origin of this ubiquitous effect, a general consensus is that both the steric (more specifically electrostatic) and hyperconjugative interactions contribute. Here we employed the block-locali...
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Non-native protein aggregation is a prevalent problem occurring in many biotechnological manufacturing processes and can compromise the biological activity of the target molecule or induce an undesired immune response. Additionally, some non-native aggregation mechanisms lead to amyloid fibril formation, which can be associated with debilitating diseases. For natively folded proteins, partial o...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2016
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2016.08.006